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Description

Hyperuricemia is associated with several cardiovascular, metabolic and renal co-morbidities that may complicate its management. There is a growing evidence that hyperuricemia is an independent risk factor for hypertension, Myocardial Infarction (MI), Coronary Heart Disease (CHD), stroke, metabolic syndrome and its components and Chronic Kidney Disease (CKD).

Urate-lowering therapy is used to treat hyperuricemia in patients with gout with a goal to reduce serum urate to 6.0 mg/dL or less. This ultimately improves the clinical symptoms of gout by reducing the frequency of gout flares, decreasing size and number of tophi and improving quality of life. Control of hyperuricemia is not achieved in some patients with allopurinol, for a variety of reasons; newer therapies may be of benefit in such patients. Febuxostat is a non-purine xanthine oxidase inhibitor, approved for the treatment of chronic gout.

FOXSTAT™ is a potent, non-purine, selective inhibitor of xanthine oxidase that exhibits antihyperuricemic activity by reducing the formation of uric acid.

FOXSTAT™ has been shown to potently inhibit both the oxidized and reduced forms of xanthine oxidase. Unlike FOXSTAT™, administration of allopurinol does not provide persistent enzyme inhibition and has weaker hypouricemic activity.

FOXSTAT-40^® FOXSTAT-80^® TABLETS

(ANTI HYPERURICEMIC AGENT)

Composition

FOXSTAT - 40™

Each film coated tablet contains:
Febuxostat ................................................................... 40 mg
Excipients .................................................................... q.s.
Colours: Red Oxide of Iron,
Lake of Indigo Carmine (C.I.No.73015),
Titaniun Dioxide I.P

FOXSTAT - 80™

FOXSTAT - 80™
Each film coated tablet contains:
Febuxostat ................................................................... 80 mg
Excipients .................................................................... q.s.
Colours: Lake of Erythrosine (C.I.No.45430)
Lake of Indigo Carmine (C.I.No.73015)
Titaniun Dioxide I.P